23,24 In short, the reduced emotional responsiveness of individuals with elevated

psychopathic traits could be a secondary consequence of heightened top-down attentional control to non-emotional stimulus features.25 In recent studies in adults with psychopathy, Newman and colleagues manipulated attention either towards the threat-relevant component of a stimulus array or away Inhibitors,research,lifescience,medical from this component and examined fear-potentiated startle (FPS).3,4 In each of these studies, psychopathy scores were significantly inversely related to FPS under conditions that required participants to focus on a threat-irrelevant dimension of stimuli. In contrast, psychopathy scores were unrelated to FPS when attention was focused on the threat-relevant dimension. These studies provide important support for the suggestion that it is an attentional abnormality, rather than a problem in emotional responding, that is central

to an understanding of psychopathy. Given the literature on the interaction of top-down attentional Inhibitors,research,lifescience,medical control and emotional responding,23,24 these data should suggest that psychopathy is related to enhanced recruitment of regions implicated in top-down attentional control (ie, dorsomedial and lateral frontal and parietal cortices26). The stronger these Inhibitors,research,lifescience,medical are recruited (as a function of psychopathy), the stronger the priming of threat irrelevant stimulus dimensions, the weaker the representation of threat relevant stimulus dimensions following Caspase inhibitor representational competition, and the weaker the emotional response. However, there are at least five reasons to be cautious. Inhibitors,research,lifescience,medical First, while these are correlational studies within a forensic sample, and thus studies where IQ could not be matched across groups, it remains critical to show that IQ did not correlate with psychopathy level. Otherwise the results might reflect the influence of IQ rather than psychopathy. However, Inhibitors,research,lifescience,medical this matching was not done. Second, only the individuals with psychopathy showed an impact of the attentional manipulation. Individuals low in psychopathy showed no differentiation in their fear-potentiated startle as a function of whether attention was directed ADAMTS5 towards

or away from threat-relevant stimulus features. It is currently unclear why this paradigm contrasts with other work showing that manipulations of attention do have an impact on emotional responding in healthy individuals.23,24 Third, while superior recruitment of top-down attentional control systems would result in reduced emotional responses to emotional stimuli that are not the focus of attention, there are no indications of increased recruitment of such systems in the studies showing reduced amygdala responses to emotional stimuli in adults with psychopathy. Fourth, several studies have shown reduced FPS in individuals with psychopathy to environmental threats in the absence of task demands to attend to other stimulus features.