910), the CD4 percentage (P=0.928), or HIV RNA levels (P=0.713); the last available HIV RNA values were also similar (P=0.995), but the patients who did not undergo an OGTT had lower last available CD4 counts BKM120 [median (IQR) 360 (238–425) vs. 502 (327–628) cells/μL for those undergoing

OGTT; P=0.013] and last available CD4 percentages [median (IQR) 19% (17–23%) vs. 24% (19–29%), respectively; P=0.045]. The 84 evaluable patients [67 male (80%); median age 45.7 years (range 43.8–49.1 years)] were all Caucasian; 65 (77%) were coinfected with HCV and seven (8%) with HBV; 15 (18%) had a previous AIDS-defining event; 58 (69%) had previously received stavudine and 44 (52%) indinavir. At the time of the study evaluation, 64 patients (76%) had undetectable HIV RNA levels (<50 copies/mL); median (IQR) exposure to any antiretroviral regimen was 12.8 (10.4–16.5) years, with median (IQR) exposure to NRTIs being 11.2 (4.2–18.3) years, that to NNRTIs 1.2 (0.4–2.7) years, and that to PIs 5.9 (2.6–8.0) years. The last available median (IQR) values were: CD4 count, 502 (327–628)cells/μL; CD4 percentage, 24% (19–29%); FPG level, 81 (75–87) mg/dL [4.5 (4.2–4.8) mmol/L]; total cholesterol, 182 (158–203) mg/dL [4.7 (4.1–5.3) mmol/L]; HDL cholesterol, 41 (35–49) mg/dL [1.1 (0.9–1.3) mmol/L]; LDL cholesterol, 103 (81–129) mg/dL [2.7 (2.1–3.3) mmol/L]; and

triglycerides, 130 (92–196) mg/dL [1.5 (1–2.2) mmol/L]. Median (IQR) BMI was 22.9 (21.2–25.5) kg/m2 AZD2281 solubility dmso and median (IQR) waist circumference was 82 (77–88) cm; 55 patients (73%) had a BMI of <25, 16 patients (21%) had a BMI of 25–29.9, and four patients (5%) had a BMI of ≥30 kg/m2; and 71 (84%) and 13 Hydroxychloroquine in vitro (15%) had normal and abnormal waist circumferences, respectively. Eighteen out of 75 patients (24%) had a family history of DM. After the OGTT, nine of 84 patients (11%) were diagnosed as having IGT (six patients) or DM (three patients).

Table 1 shows the demographic and main clinical characteristics of the study patients by OGTT result; patients with IGT or DM had lower CD4 cell counts than those without [median (IQR) 294 (249–388) vs. 515 [342–633] cells/μL, respectively; P=0.047), while no between-group differences were observed for smoking habit, blood pressure, or use of antihypertensive medications. Table 2 shows glucose metabolism parameters in general and by the 2-h post-load results. Median (IQR) HOMA-IR was 2.82 (1.89–4.02), median (IQR) 2-h post-load glucose was 102 (83–119) mg/dL [5.7 (4.6–6.6) mmol/L] and median (IQR) 2-h post-load insulin was 35 (14.0–71.0) mIU/L. Patients with IGT or DM had higher median fasting insulin (P=0.010) and HOMA-IR values (P=0.009) than patients without IGT or DM, and there were also significant differences in 2-h post-load glucose (P<0.0001) and 2-h post-load insulin (P=0.020) levels.