After that patients were screened for depression using the NICE clinical guideline initial depression screening tool. Data was analyzed in SPSS version 17 using descriptive statistics and Univariate analysis. Results: Out of 246 patients 56.9% were male and 43.1% were female. Mean age was 35.84 years while mean duration of disease was 2.33 years. Out of all patients 28.5% of the patients belong to postprandial distress syndrome, 28.9% belong to epigastric pain syndrome while 42.7% belong to both groups.

Frequency of depression was 75.6% among patients screened for depression JNK inhibitor with 19% of the patients saying that they had thought of death in the last month. Female sex was significantly associated with depression in univariate analysis (OR 2.32, p value 0.01) while dyspepsia group or duration of the disease were not. Conclusion: Keeping in view the high prevalence of depression in functional dyspepsia all patients with functional dyspepsia must be screened for depression. Key Word(s): 1. GI Gastroenterology; 2. Rome III; Presenting Author: GSK3 inhibitor MARIE

ANTOINETTEDE CASTRO LONTOK Additional Authors: ROMMELPARULAN ROMANO, JOSEDECENA SOLLANO Corresponding Author: MARIE ANTOINETTEDE CASTRO LONTOK, ROMMELPARULAN ROMANO Affiliations: Asian Hospital and Medical Center; University of Santo Tomas Hospital Objective: The diagnosis of gastroesophageal reflux disease (GERD) in the community is largely based on the clinicians’ assessment of the symptom presentation by patients. The locally-validated

Filipino version of the Frequency Scale of Symptoms of GERD (FSSG) was used to investigate the most common symptoms associated with reflux in the primary care setting in the Philippines, as well as, determine response to PPI treatment. Methods: Patients presenting with Linifanib (ABT-869) reflux symptoms seen by primary care physicians were recruited. The FIlipino version of the FSSG questionnaire were administered before and after completion of PPI treatment. Patients were given 4 weeks of Rabeprazole 20 mg once a day. Pre and post treatment F test scores were computed. Outcome measured was resolution or non-resolution of symptom/s after PPI treatment. Data were collated and statistical analysis done using SPSS v20. Results: A total of 1,578 subjects were enrolled and analyzed in this study. The most common symptom presented was a sensation of heartburn present in 1,359 (86.12%) of the subjects, followed by bloatedness (83.52%). Evaluating response to treatment, there was a statistically significant difference between the pre- and post-treatment F test scores (p < 0.001). The highest positive symptom response was seen pertaining to sour taste in the mouth (90.3%) and the symptom least responsive to PPI therapy is feeling ill after a binge meal (81.9%). Conclusion: Using the locally validated FSSG questionnaire, the most common clinical presentation of GERD patients include heartburn and bloatedness.