Each hour of delay in appropriate antimicrobial therapy was assoc

Each hour of delay in appropriate antimicrobial therapy was associated with an 86% increase in the odds of in-hospital mortality.

Admission APACHE II and serum lactate also significantly impacted mortality. Earlier identification of septic shock and initiation of appropriate antimicrobial therapy could potentially improve outcomes. A,B,C: Predicted death according to APACHE II, lactate, time to antimicrobials. D: Time to antimicrobials adjusted for APACHE II scores. Disclosures: Constantine J. Karvellas – Grant/Research Support: Merck; Speaking and Teaching: Gambro Juan G. Abraldes – Speaking and Teaching: Gore, Janssen The following people have nothing to disclose: Yaseen Arabi, Anand Kumar Identification of patients with Spontaneous Bacterial Peritonitis (SBP) at risk of organ failure and death is challenging. Aims: To evaluate Selinexor ic50 the association of procalcitonin (PCT) with acute-on-chronic liver failure (ACLF) or death in patients with SBP. Methods: Adult cirrhotic patients with SBP were prospectively included from

October 2012 to March 2014 in 3 Liver Units. Patients with a prior episode of ACLF (CLIF-Consortium) in the 30 days before the inclusion and patients with end-stage hepa-tocellular carcinoma, organ transplantation, immunosuppres-sion or active alcohol drinking were excluded. Procalcitonin (measuring range: 0.02-100 ng/mL) was collected at the time of SBP diagnosis and before antibiotic initiation. Investigators were blinded to PCT results. Primary outcome was ACLF or death at 30 days of SBP diagnosis. Tyrosine Kinase Inhibitor Library purchase Results: Forty one consecutive patients with SBP were included. Overall, ACLF was diagnosed in 27 (66%) patients, 11 (27%) died. In the univariate analyses, patients with ACLF or death had significantly higher PCT, Child-Pugh score, MELD, INR and creatinine than patients without ACLF or death (Table). The OR for ACLF or death for every

0.1 ng/mL increase of PCT was 1.34 (CI 95% 1.071.67, p 0.01). After adjusting for age, MELD, creatinine and positive blood cultures, the OR was 1.75 (CI 95% 1.05-2.93, p 0.033). From a receiver operating characteristic curve, a PCT cut-off point of 0.95 ng/mL was identified with 上海皓元医药股份有限公司 sensitivity 67% and specificity 100% for predicting ACLF or death. Positive and negative predictive values were 100% and 61%, respectively. Conclusion: In patients with SBP, PCT is a strong predictor of bad outcomes. A PCT of > 0.95 ng/mL at diagnosis of SBP identifies patients at high risk of ACLF or death. *Median (IQR), **Mean ± SD, *** Hepatocellular Carcinoma, **** Systemic Inflammatory Response Syndrome. Disclosures: The following people have nothing to disclose: Sebastian Marciano, Natalia Sobenko, Alfredo Martinez, Manuel Mendizabal, Luis A. Gaite, Federico Pinero, Leila Haddad, Marcelo O. Silva, Ezequiel Ridruejo, Oscar G. Mando, Diego H.

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