This will provide a useful in vivo way to study tubular regeneration in the context of the whole organism and, also, to interrogate the process in different injury models and when the environment is altered with small molecules.

A major question that remains is the identity and workings of the molecular events that regulate renal regeneration after acute injury. Identifying the pathways that regulate the behavior of reparative epithelia would address a major gap that exists in the field of nephrology. Through the success of using zebrafish chemical genetics approaches to gain insights into AKI and polycystic kidney disease,73 and 94 it is clear that recent work has established the essential groundwork to study OSI-744 solubility dmso renal regeneration and disease using the zebrafish. The similarities in tubular regeneration events between zebrafish and mammals support the notion that many molecular signals and mechanisms may be conserved between these species. Ultimately, the discovery of renal progenitors capable of neonephrogenesis in the zebrafish adult opens a new portal for clinical studies given the ability to induce cell type changes with defined factors. Knowledge of the critical regulators that define the renal progenitor Ribociclib mouse identity could allow researchers to test if controlled expression of these genes can induce nephrogenesis in the mammalian kidney—which would constitute a major breakthrough

for the treatment of kidney disease. Current and future studies in zebrafish are an exciting research area that may identify renal regeneration pathways and/or repair mechanisms, and therefore provide formative clues concerning the recipe of signals that are essential to mediate kidney regeneration

in humans. The authors thank the staffs of the Department of Biological Sciences and the Center for Zebrafish Research for their support, and the members of our research lab for stimulating conversations about this topic. “
“Dongsheng Fei, Xianglin Meng, Mingran Zhao, Kai Kang, Gang Tan, Shangha Pan, Yunpeng Luo, Wen Liu, Chuanchuan Nan, Hongchi Jiang, Geoffrey W Krissansen, Mingyan Zhao, Xueying Sun Enhanced Cediranib (AZD2171) induction of heme oxygenase-1 suppresses thrombus formation and affects the protein C system in sepsis Translational Research 2012;159:99-109. In the February 2012 issue of Translational Research, one of the corresponding author’s information was omitted. The following author is also a corresponding author for this article. Reprint requests: Mingyan Zhao, MD, PhD, Department of ICU, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China; e-mail: [email protected] “
“We wish to acknowledge the outstanding contribution of our reviewers and Editorial Advisory Board. The quality and breadth of the Journal is only made possible by the dedicated efforts of our reviewers. Joseph Ahearn S.