Methods: A total of 208 pregnant women in the last trimester were included in the study. A questionnaire about socio-demographic status, consumption of meat, egg, milk-dairy products, multivitamin supplementation was used. Vitamin B-12 and folate concentrations were studied by chemiluminescence method. The babies of Vitamin B-12 deficient mothers were evaluated after birth. Results: Danusertib The rate of vitamin B-12 deficiency was 47.6% and folate deficiency was 17.3% of pregnant women. Animal food consumption was inadequate about

half of pregnant women and vitamin B-12 levels in these women were significantly low. There were no statistically significant relationships between the birth weight, birth length and head circumference measurements, and maternal vitamin B-12 and folate concentrations. Conclusion: The rate of vitamin B-12 deficiency in pregnant women in low socioeconomic population is high. selleck compound Although there were no significant effects of the vitamin B-12 and folate deficiencies on birth size, additional studies are required to elucidate the subsequent effects.”
“An expeditious synthesis of 5,7-dihydroxy-6-methylphthalide from open-chain precursors is described. The key intermediates, synthons 3 and 4, were readily obtained

from accessible materials and were further transformed to a common precursor, a five-membered lactone derivative, via an intramolecular Michael addition. Lactone 2 was aromatised to the phthalide system under basic conditions. The process thus constitutes a formal synthesis of the phthalide framework.”
“Introduction: Thrombocytopenia affects about 10% Copanlisib of all pregnancies. Preeclampsia/HELLP syndrome induced thrombocytopenia may associate perinatal morbidity, preterm delivery,

or low-birth-weight newborns. Objective: To assess perinatal outcome and complications of pregnancy in women presenting with thrombocytopenia. Methods: We retrospectively analyzed 936 consecutive pregnant women admitted during a 6-month period. Results: Incidence of thrombocytopenia in pregnancy was 11.11% (104/936). Thrombocytopenia represented a risk factor for premature delivery-highest risk for severe thrombocytopenia (RR = 8.69, p < 0.01). Thrombocytopenic preeclampsia or HELLP syndrome associated the highest rates of prematurity (RR = 7.97, p = 0.00, respectively 12.32). Thrombocytopenia also represented a risk factor for low-birth-weight newborns, especially severe thrombocytopenia-2047.50 +/- 938.98 g (p = 0.02) versus 3224.86 +/- 496.00 g in controls. Again, thrombocytopenic preeclampsia was significantly associated with low-birth-weight newborns (RR = 11.94, p = 0.00), with medium weight of 2462.05 +/- 794.54 g versus 2932.37 +/- 708.91 g in thrombocytopenic pregnancies, respectively 3224.86 +/- 496.00 g (p = 0.00) in normal pregnancies.