Scores above 50 in either category indicate the patient has no disability. Scores under 50 indicate increasing levels of disability AZD6738 compared to the general population (40–50 = mild disability, 30–40 = moderate disability, <30 = severe disability).[8] FFR is a valuable reconstructive option in high-risk patients with success rates as high as 80%.[9] Beyond successful limb salvage, we showed that the ability to ambulate significantly increased one's physical HRQoL and that ambulatory patients could achieve a HRQoL comparable to that of the general population. Factors such as the development of either immediate
or late complications did not influence HRQoL. The physical HRQoL scores as measured by the SF-12 in our patient cohort showed only mild disability compared with the general population when ambulation was achieved (82% of patients). This was in contrast to decreased physical HRQoL for nonambulatory patients post-operatively. Mental HRQoL was comparable with the general population for both ambulatory and nonambulatory patients. Another important factor influencing
HRQoL was amputation. We showed that patients had a higher find more physical HRQoL (comparable with that of the general population) when they did not undergo an amputation. However, this value continued to be influenced by the ambulatory status of the patient. Ambulatory patients showed only mild disability regardless of amputation status, and there was no difference between the physical HRQoL of ambulatory amputees and nonamputees. However, the HRQoL decreased dramatically for both amputees and nonamputees when these patients were not ambulatory. Interestingly, although both groups showed severe Rucaparib solubility dmso disability, the HRQoL was significantly higher for ambulatory amputees than nonambulatory nonamputees, further suggesting that the ability to ambulate was the main factor influencing HRQoL. This cohort of patients required a high rate of revisional surgeries (61% of patients) to achieve a successful outcome. Although the great majority of these additional surgical procedures were minor, subjecting patients to multiple surgeries could conceivably reduce their satisfaction with
the initial procedure. Despite this concern, we found that 95% of patients would choose to undergo FFR again if given the choice, with average patient satisfaction of 4.89 on a 5-point scale. The high level of HRQoL in ambulatory patients is a desirable result after FFR of the lower extremity. Although various other studies have previously reported evidence of patient satisfaction or HRQoL outcomes following FFR, none has so far employed the use of a validated questionnaire in this patient cohort.[10, 11] The evidence has thus far been sporadic and largely anecdotal. Of course, there are limitations to this study as well, such as the potential for self-selection bias. However, the near-equal response rate between ambulatory and non-ambulatory populations is reassuring.