029 °C per milliwatt of power dissipated by an electrode array with 100 electrodes, however the power dissipation was based on the system operating as a neural recording device only; we expect that a stimulating array would not only influence local temperatures via increasing metabolism, but it would also consume

more power and result in greater heat accumulation. While further study in this area is clearly required to determine the safe limits of operation for a multi-array cortical visual prosthesis, a possible solution to the problem may be incorporating temperature sensors into the implants, which was recently demonstrated in a subretinal visual prosthesis (Liu et al., 2014). Preventing the ingress of bodily fluids will be essential for maintaining

the functionality and longevity of a visual prosthesis, ABT-263 ic50 and will require the tight sealing of all joins between materials comprising the electrode arrays. A detailed treatment of the engineering, materials design and manufacturing issues involved is beyond the scope of this review, however it is noteworthy that in-vitro testing of an encapsulated Utah slant array over a period of 9 months JAK pathway revealed no deterioration of device performance that would indicate a failure of hermetic sealing (Sharma et al., 2011). Moreover, with reports of neural recording arrays functioning in-vivo in humans (Hochberg et al., 2012) over periods of 5 years, manufacturing techniques have clearly developed to the point that maintenance of array hermeticity over the lifespan of the visual prosthesis will be achievable. The rapidly growing field of medical bionics offers the potential of partially restoring visual function in individuals with severe visual impairment. We have summarized the clinical imperative for a cortical visual prosthesis, the general design principles and some of the major hurdles facing research groups who are currently developing this technology. Our research group, based

at Monash University in Melbourne, Australia, is developing a wireless prosthetic vision system based on cortical microstimulation (Fig. 3) (Lowery, 2013). The project is nearing technical completion, and preclinical, biocompatibility and functional testing of an implantable device is currently underway in normally-sighted sheep and macaques. Farnesyltransferase We anticipate that the results of this study, and others reporting similar progress in the field, should underpin the imminent trial of a new generation of cortical visual prostheses in humans. The authors would like to thank Dr. Jeanette Pritchard for her assistance with proofreading the manuscript, and Mr. Gavin Hawkins for his assistance with the preparation of Fig. 3. This project is funded through the Australian Research Council׳s Research in Bionic Vision Science and Technology Initiative (SRI 1000006). “
“Apoptosis signal-regulating kinase 1 (ASK1, also referred to as MAP3K5)(Ichijo et al.