There are also no data available regarding its changes following bariatric surgery.
The present study examined weight loss, and salivary ghrelin and HMW adiponectin levels in 43 morbidly obese subjects undergoing three different types of bariatric surgery.
We found that
weight loss following LSG is superior to laparoscopic adjustable gastric banding (LAGB) and comparable 3-Methyladenine to RYGB at 12 months after surgery. Although blood glucose decreased similarly following all three procedures, fasting insulin continuously declined only in LSG and RYGB patients. Changes in both fasting and postprandial salivary ghrelin greatly varied between all three procedures with no similarities to changes in serum ghrelin reported in the literature. HMW adiponectin significantly increased following LSG, and this increase was more marked than in LAGB patients and almost identical compared to RYGB.
Weight loss following LSG is comparable to RYGB in the short term.
Changes in HMW adiponectin are comparable following LSG and RYGB which may further contribute to the successful results after LSG. Furthermore, the results of the present study support the hypothesis that there is an autonomous production of ghrelin in salivary glands irrespective of nutritional status and weight loss.”
“Background and purpose: Exome sequencing in a large essential tremor (ET) family identified a novel nonsense mutation (p.Q290X) in the fused in sarcoma gene (PUS) as the cause of this family. Because of the clinical overlap between ET and Parkinson’s disease (PD), the role of FUS in an independent cohort of Napabucasin chemical structure PD patients from China ZD1839 mainland was evaluated.
Methods: The entire coding region of FUS in 508 Chinese Han patients with PD and the identified variants in 633 normal controls were evaluated. A variant was further screened in an additional 382 controls for the frequency in our population.
Results: A novel variant c.696C > T (p.Y232Y) in 2 sporadic patients with PD and six variants (c.52C > A, p.P18T; c.52C > T, p.P18S; c.147C > A, p.G49G; c.291C > T, p.Y97Y; c.684C > T, p.G228G; c.1176G > A, p.M392I) without significant
difference in genotypic and allelic distributions in our PD cohort were identified.
Conclusion: The FUS gene is not a genetic risk factor for PD in the population of Chinese Han ethnicity. (C) 2013 Elsevier Ltd. All rights reserved.”
“Objective. To determine circadian rhythms of circadian genes in the peripheral blood mononuclear cells in preterm neonates.
Study design. Ten premature neonates, gestational age from 30 to 31 weeks were recruited. Infants with birth asphyxia, RDS, apnea, malformation, infection or haemolytic diseases were excluded. At 7AM and 7PM on the 1st day, 7th day and 14th day of hospitalisation, peripheral venous blood was obtained from the premature babies and real-time RTPCR was used to determine the expression of Bmal1 and Cry1.