Data analyses were conducted using Epi Info 6.0 and Statistical Package for Social Sciences (SPSS 13.0). 84 case-control
pairs matched by gender, age, admission period, morbidity, and underlying disease were analyzed. The mean lengths of hospital stay were 48.3 and 16.2 days for cases and controls, respectively (p<0.01), yielding an excess hospital stay among cases of 32.1 days. The excess mortality among cases compared to controls that was attributable to S. aureus bloodstream infection was 45.2%. Cases had a higher MK-2206 concentration risk of dying compared to controls (OR 7.3, 95% CI 3.1-21.1). Overall costs of hospitalization (SIH/SUS) reached US$ 123,065 for cases versus US$ 40,247 for controls (p<0.01). The cost of antimicrobial therapy was 6.7 fold higher for cases compared to controls. Healthcare-associated S. aureus BSI was associated with statistically SBE-β-CD molecular weight significant increases in length of hospitalization, attributable mortality, and economic burden. Implementation of measures to minimize the risk of healthcare-associated bacterial infections is essential. (C) 2012 Elsevier Editora Ltda. All rights reserved.”
“Background: Corm is a senile protease that cleaves pro-atrial and pro-B-type natriuretic peptides into biologically
active hormones The relationship between soluble
plasma corm levels, plasma natriuretic peptide levels, myocardial structure and performance. and long-term clinical outcomes in the setting of chronic systolic heart failure has not been described
Methods and Results: In 126 patients with chronic systolic heart failure (left ventricular ejection fraction <= 35%. New York Heart Association functional Class I-IV), we measured plasma corin and natriuretic peptide levels and performed comprehensive echocardiography with assessment of cardiac structure and performance Adverse clinical events (all-cause mortality, cardiac transplantation, SNX-5422 clinical trial or heart failure hospitalization) were prospectively tracked for a median of 38 months Plasma corm levels modestly correlated with echocardiographic indices of cardiac structure, including left ventricular mass index (r = 0 30. P = 003) and interventricular septum width (r = 0 22, P = .013) However, plasma corm levels did not con elate with am arterial pressures, estimated glomerular filtration rate, echocardiographic indices of systolic or diastolic function. or plasma natriuretic peptide levels In Cox proportional hazards analysis, higher plasma corm levels did not predict reduced risk of adverse clinical events (hazard ratio 0 91, 95% confidence interval 0 67-1 24, P = 52).