I had begun to sense that a comprehensive source of information on the neurology of the newborn was needed, i.e., a book. When I discussed preparation of a book in this fledgling field, he cringed and advised me not to do it. He felt PD-1/PD-L1 inhibitor that my academic career, especially my laboratory research, a critical component

of my career, would suffer. This advice was the only counsel from Phil that I did not heed. I wanted to take on this challenge, and I was determined to pursue the endeavor as a single author. Thus I began the preparation of the first edition of Neurology of the Newborn in the late 1970s. After several years of research and writing, this edition was published in 1981. Epacadostat ic50 There followed four subsequent editions, the last of which, the fifth edition, was published in 2008. After the first edition, the field of neonatal neurology grew explosively (see in the following), and as a consequence, the preparation of each edition was progressively more difficult. Indeed from the first book with 225 figures, 273 tables, and 3300 references, the volumes grew progressively, and in the fifth edition, 663 figures, 548 tables, and approximately 13,000 references were included.

In spite of the increasingly painful gestations, the book remained for me a labor of love. The explosion in neonatal neurology as a discipline began in the 1980s and has buy 5-Fluoracil continued to the present day. I recall in the late 1970s to early 1980s presenting our work in a few abstracts to the small Child Neurology section at the annual meeting of the Pediatric Academic Societies

(then, Society for Pediatric Research). There were essentially no presentations on neonatal neurology in the many subsections of the huge neonatology sessions at those meetings. Later, in the 1980s and into the 1990s, a dramatic increase in presentations related to neonatal neurology became apparent, such that several hundred such abstracts were accepted, and most interestingly, virtually all were chosen for neonatology subsections. Perhaps most surprisingly, the large majority of such presentations were by neonatologists. This trend has continued, such that in the present day the work on neonatal neurology presented at the Pediatric Academic Societies meeting is predominantly authored by neonatologists. The interest in this field within neonatology now rivals the traditional degree of emphasis on respiratory disease in that specialty. Indeed, current leaders in neonatal neurology include such distinguished figures in neonatology as David Edwards, Frances Cowan, Mary Rutherford in the United Kingdom, Linda de Vries in the Netherlands, Petra Huppi in Switzerland, and, of course, Jeff Perlman in the United States, among many others.