In conclusion, to the best of our knowledge,

this Proteasome inhibitor is the first report where we have put forth an evidence of potential role of SPAG9 in cellular growth, migration, invasion and colony forming ability in highly aggressive triple-negative MDA-MB-231 JNK-IN-8 mw breast cancer cells. Furthermore we also demonstrated that SPAG9 expression was higher in all breast cancer cell compared to normal mammary epithelial cells. In addition, in vivo xenograft studies further strengthen the role of SPAG9 in breast cancer. Our study provides an association between SPAG9 expression and its potential role in breast cancer, and thus lays a foundation for developing a promising therapeutic target for triple-negative breast cancer. Acknowledgements This work is supported by grants from Indo-UK Cancer Research Program, Centre for Molecular Medicine, NII-core funding, Department of Biotechnology, Government of India. We also thank technical support by Mrs. Rekha Rani, National Institute of Immunology, New Delhi, India for confocal microscopy. References 1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. CA Canc J Clin 2011, Selleck Milciclib 61:69–90.CrossRef 2. Albertson DG, Collins C, McCormick F, Gray JW: Chromosome aberrations in solid tumors. Nat Genet 2003, 34:369–376.PubMedCrossRef

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