It was suggested that one should include assessment of blood and joint fluid for nitrogen oxide, nitrate diaphorase and nitrate reductase in the algorithm of investigation and dynamic observation, choice of tactics and therapy efficiency assessment. Practical value: Obtained new data are necessary bcr-abl for increasing the pharmacotherapy efficacy in patients with rheumatoid arthritis taking into account the metabolic activity of NO synthetase mechanism in blood and synovial fluid. An algorithm was suggested for screening observation and differentiated management of patients with rheumatoid arthritis taking account of severity of nitrogen oxide metabolism disorders. A differentiated approach was worked out and justified of simvastatin prescription both to increase the efficacy of treatment taking into account the clinical activity of the disease and to correct metabolic disorders in patients with rheumatoid arthritis.

Increased angiogenesis assay prevalence of metabolic syndromein rheumatoid arthritis has been reported from American and European populations but it has not been studied in Indian patients with RA. The main objective of our study was to assess the prevalence of the metabolic syndrome in Asian Indian patients with rheumatoid arthritis and also to studyits correlation with disease activity. This was a prospective case control study in which 114 patients diagnosed to have rheumatoid arthritis of more than 1 year duration and 114 healthy age and sex matched controls were included. Height, weight, body mass index, blood pressure and waist circumference of the patients were measured at the enrolment visit.

Venous samples were taken after eight hours of overnight fasting for the estimation of serum cholesterol, triglycerides and plasma glucose levels. Metabolic syndrome was diagnosed according to Adult Treatment Panel III criteria Cellular differentiation and the consensus definition of the metabolic syndrome for adult Asian patients. The disease activity was assessed by DAS 28. The mean age of patients with RA and control group was 44. 8 and 43. 2 years respectively. The mean duration of RA was 6. 5 years. Though the mean BMI was similar in both the groups, there was a statistically highly significant difference in mean waist circumference and diastolic blood pressure in patients with RA as compared to controls.

Metabolic syndrome was present in 36 patients 850649-61-5 Alogliptin and 17 controls according to the Adult Treatment Panel III criteria and in 40 patients and 18 controls according to the consensus definition of the metabolic syndrome for adult Asian patients. There was no significant correlation between the metabolic syndrome and disease activity as measured by DAS 28 using both the criteria. Indian patients with RA have increased prevalence of metabolic syndrome as compared to their age and sex matched healthy controls, but there is no significant correlation between metabolic syndrome and disease activity. Osteoprotegeirn is an endogenous decoy receptor for RANKL, which is a cytokine essential for osteoclast differentiation. Lipopolysaccharide is known to induce osteoclast formation when injected onto calvaria in mice. Unexpectedly, we observed that mice injected with LPS up regulate OPG and down regulate RANKLlevels in peripheral blood.