Key Word(s): 1. Postcholecystectomy; 2. diarrhoea; 3. Diagnosis criteria; 4. Prediction; Presenting Author: HIROYUKI TAMAKI Additional Authors: AKIKO NOGAMI, TERUYO NODA, YUMIKO MORIOKA, SOUICHI ARASAWA, YUKIKO MIYAMOTO, MASAKO IZUTA, TETSURO ISHIKAWA, TOSHIHIRO MATSUNAKA, CHIKARA OGAWA, MITSUSHIGE SHIBATOGE Corresponding Author: HIROYUKI TAMAKI Affiliations: Takamatsu Redcross Hospital Objective: Although some studies have reported the efficacy of percutaneous transhepatic gallbladder aspiration (PTGBA) as alternative therapy for the treatment of acute cholecystitis

with fewer Temsirolimus manufacturer complications, the clinical usefulness of PTGBA has not yet been fully examined. We evaluated the efficacy and safety of PTGBA for the treatment of acute cholecystitis compared with percutaneous transhepatic gallbladder INCB018424 purchase drainage (PTGBD) and surgical treatment. Methods: A total of 76 patients, median age 67 years old, with acute cholecystitis was included to this study. PTGBA was performed in

36 patients and 30 patients were treated with PTGBD. Remaining 10 patients were performed an emergency surgery. Results: PTGBA were successful in all patients and achieved improvement in 30 of 36 patients (83.4%). In 3 (8.3%) of the remaining 6 patients, PTGBD was undergone because of recurrence. Biliary peritonitis was occurred in 3 patients (8.3%) and treated with emergency surgery. One of them showed high viscosity of the bile and open surgery revealed that the bile

leaked out to the surface of the liver through puncture hole. In the remaining two, torsion of gallbladder and rupture of necrotic gallbladder were observed. PTGBD were successful in 29 of 30 patients and all cases of success were improved without any complications. All patients treated by emergency surgery were improved without any complications. There was no difference in the improvement of WBC and CRP in 5 days after treatment between each group. Mean length of hospital stay was 上海皓元 significantly shorter in patients treated with PTGBA than others (p < 0.05). In patients treated with PTGBA, there was no correlation between the volumes of puncture fluid or bacterial strain cultured from removed bile and the effect of treatment. Recurrence was tending to observe more frequently in patients with biliary sludge and no gallstones than patients with both of them or only with gallstones. Although abdominal pain was ameliorated within 12 hours after PTGBA in successfully treated patients, was not ameliorated in patients with biliary peritonitis even after 12 hours. Conclusion: PTGBA is a simple and useful therapy for the treatment of acute cholecystitis. However, it is important to pay attention to development of complications especially in patients with high bile viscosity, torsion of gallbladder, and necrotic cholecystitis. Key Word(s): 1. acute cholecystitis; 2.