Monoclonal antibodies targeting CD4, CD19, CD20, CD22, CD23, CD25, CD45, this website CD66 and CD122 are now being studied in the clinic for the treatment of leukaemia. Here, we discuss
how these new antibodies have been engineered to reduce immunogenicity and improve antibody targeting and binding. Improved interactions with Fc receptors on immune effector cells can enhance destruction of target cells through antibody-dependent cellular cytotoxicity and complement-mediated cell lysis. The antibodies can also be armed with cellular toxins or radionuclides to enhance the destruction of leukaemia cells.”
“Hollow polymer latex particles containing a hydrophilic core were prepared by seeded emulsion Polymerization with MAA/BA/MMA/St as comonomers, followed by stepwise alkalization treatment with ammonia. The size and morphology of composite latex particles was determined by TEM. The effects of RG-7112 concentration the seeded emulsion polymerization conditions and alkalization treatment on the size and hollow structure of latex were investigated. The results showed that the optimum content of crosslinking agent in the shell polymers was about 0.5-1.0 wt %, emulsifier was about 0.8-1.1 wt %, and the core/shell weight ratio was 1/7. To obtain uniform hollow latex Particles with size, the starved feeding, technique should be adopted in seeded emulsion polymerization and the neutralization temperature should equal to the
T(g) of the shell polymer. Then, the obtained
polymer particles under this condition had an excellent hollow structure. (C) 2009 Wiley Periodicals, Inc. J Appl BMS-777607 order Polym Sci 113: 207-215, 2009″
“Mastitis is the most common infectious disease affecting dairy cattle; in addition, it remains the most economically important disease of dairy industries around the world. Streptococcus agalactiae, a contagious pathogen associated with subclinical mastitis, is highly infectious. This bacterium can cause an increase in bulk tank bacterial counts (BTBC) and bulk tank somatic cell counts (BTSCC). The microbiological identification of S. agalactiae in samples from bulk tanks is an auxiliary method to control contagious mastitis. Thus, there are some limitations for time-consuming cultures or identification methods and additional concerns about the conservation and transport of samples. Bulk tank samples from 247 dairy farms were cultured and compared through polymerase chain reaction (PCR), directed to 16S rRNA genes of S. agalactiae, followed by BTBC and S. agalactiae isolation. The mean value of BTBC was 1.08 x 10(6) CFU mL(-1) and the bacterium was identified through the microbiological method in 98 (39.7%; CI95% = 33.8-45.9%) and through PCR in 110 (44.5%; CI95% = 38.5-50.8%) samples. Results indicated sensitivity of 0.8571 +/- 0.0353 (CI95% = 0.7719-0.9196) and specificity of 0.8255 +/- 0.0311 (CI95% = 0.7549-0.8827).