Nakae D, Kobayashi Y, Akai H, Andoh N, Satoh H, Ohashi K, Tsutsumi M, Konishi Y: Involvement of 8-hydroxyguanine formation in the initiation of rat liver carcinogenesis by low dose levels of N-nitrosodiet hylamine. Cancer Res 1997, 57: 1281–1287.PubMed 28. Ampy FR, Williams AO: Dimethylnitrosamine metabolism: I. In vitro activation of dimethylnitrosamine to mutagenic substance(s) by hepatic and renal tissues from three inbred strains of mice. Life Sci 1986, 39: 923–930.CrossRefPubMed 29. Jeong JH, An JY, Kwon YT, Rhee JG, Lee YJ: Effects of low dose quercetin: Cancer cell-specific inhibition

of Vorinostat concentration cell cycle progression. J Cell Biochem. 2009, 106 (1) : 73–82.CrossRefPubMed 30. Wang IK, Lin-Shiau SY, Lin JK: Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer 1999, 35: 1517–1525.CrossRefPubMed 31. Granado-Serrano AB, Martín MA, Bravo L, Goya L, Ramos CRT0066101 price S: Quercetin Induces Apoptosis via Caspase Activation, Regulation of Bcl-2, and Inhibition of PI-3-Kinase/Akt and ERK Pathways in a Human Hepatoma Cell Line (HepG2). J Nutr 2006, 136: 2715–2721.PubMed 32. Chaumontet C, Suschetet M, Honikman-Leban E, Krutovskikh VA, Berges R, Le Bon AM,

Heberden C, Shahin MM, Yamasaki H, Martel P: Lack of tumor-promoting effects of flavonoids: Studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication. Nutr Cancer 1996, 26: 251–263.CrossRefPubMed 33. Avila MA, Juan AV, José C, Vicente N: Quercetin Mediates the Down-Regulation of Mutant p53 in the Human Breast Cancer Cell Line Z-DEVD-FMK nmr MDA-MB468. Cancer Research 1994, 54: 2424–2428.PubMed 34. Takehiro E, Tang Q, Denda A, Noguchi O, Kobayashi E, Tamura K, Horiguchi K, Ogasawara H, Tsujiuchi T, Nakae D, Sugimura1 Oxymatrine M, KonLshi Y: Inhibition by acetylsalicylic acid, a cyclo-oxygenase inhibitor, and p-bromophenacylbromide, a phospholipase A2 inhibitor,

of both cirrhosis and enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats. Carcinogenesis 1996, 17: 467–475.CrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions AMS: Carried out the molecular genetic studies, participated in the design of the study, performed the statistical analysis, conceived of the study, and participated in its design and coordination. SSI: Carried out the immunoassays, conceived of the study and participated in its design and coordination TKE: Participated in the design of the study and performed the statistical analysis. EEH: Carried out the molecular genetic studies, participated in the design of the study, performed the statistical analysis, conceived of the study, and participated in its design and coordination.