Systematic studies of the current versus voltage

and light-emitting behavior of the OLEDs have identified different excitation processes for the two dyes. It is suggested that electroluminescence from the FIrpic molecules originates by direct transfer of the exciton energy from the PVK to the dye molecules, while the process of light emission from the Ir(piq)(2)(acac) molecules involves carrier trapping. The efficiency of the devices can be tuned, to some extent, by varying the thickness of the organic film. Luminous efficiencies and luminous power efficiencies of 8 cd A(-1) and 3 lm W-1 were measured for these blended-layer OLEDs, with Commission Internationale de l’Eclairage coordinates of 0.35, 0.35. (C) 2009 American Institute of Physics. [doi: 10.1063/1.3226780]“
“Reprogramming of energy metabolism, such as increased glycolysis, is a hallmark of cancer cells. One mechanism by which cancer cells Selleck ALK inhibitor fuel glycolysis is through increased uptake of glucose across cell membranes via the glucose transporter GLUT1. One of the transcriptional

repressors of GLUT1 is wild-type TP53, and cancer-associated loss of function mutations within the DNA-binding domain of TP53 impairs the repressive effect of TP53 selleck on transcriptional activity of the GLUT1 gene promoter. Because TP53 mutations are associated with unfavorable histology (diffuse anaplasia) in Wilms tumors, we hypothesized increased expression of GLUT1 in these tumors. To evaluate this hypothesis, we performed tissue microarray-based immunohistochemistry for GLUT1 in a set of 50 Wilms tumors, including 5 with unfavorable histology. In a subset of 16 favorable histology Wilms tumors, we compared the GLUT1 immunoexpression with TP53 codon 72 polymorphism status. We found consistently stronger immunoexpression of GLUT1 in unfavorable histology Wilms tumors compared to favorable histology Wilms tumors (P = 0.04). We noted that the favorable histology Wilms tumors with

a proline residue at position 72 of TP53 tended to have higher immunoexpression of GLUT1, although this immunoexpression did not reach statistical significance in this small set of cases. In summary, our finding BMS-345541 datasheet of strong GLUT1 immunoexpression in unfavorable histology Wilms tumors indicates that these tumors are likely to be 2-deoxy-2-(F-18) fluoro-D-glucose avid and that GLUT1 should be evaluated as a therapeutic target for these tumors that otherwise show resistance to conventional therapy.”
“Background: Hypothermia is used to preserve organs for transplantation and is the oldest method to protect organs during complex pediatric cardiac surgery. Loss of tissue function and tissue edema are common complications in children undergoing corrective cardiac surgery and heart transplantation.