the gross and microscopic changes were significantly ameliorated by pre-treatment with a single injection of ibuprofen. The IL 1 and IL l/TNF induced ATP-competitive Chk inhibitor leukopenia and thrombocytopenia was also prevented by ibuprofen. These results are in line with findings showing that ibuprofen reduces neutrophil adherence and responses to chemotactic facets. This fall in WBC has also been observed in humans during recent studies in which 2 3 ug/kg of intravenous TNF induces a sudden decline in circulating neutrophils, along with hypotension and fever. Hence, the potential usage of intravenous cyclooxygenase inhibitors in clinical situations in which TNF and IL 1 initiate or mediate the shock like state is suggested by the information presented in this report. Obviously Papillary thyroid cancer the particular indications for the drug are removed from certain. In those requiring an NSAID who produce a gastric ulcer, misoprostil could be befitting healing. However, whether this can actually prevent serious morbidity is as yet unanswered. There’s currently a renewed fascination with antacid therapy in peptic ulcer infection. Aluminium-containing antacids are not simply p neutralizing agencies but also have a mucosal protective function via stimulation of prostaglandin synthesis. 02 This gives them to prevent, for instance, alcohol-induced gastric mucosal damage. 103 Furthermore, they might be useful as a low priced maintenance therapy to stop duodenal ulcer relapse. Maalox includes in 251 individuals with healed duodenal ulcers and aluminium hydroxide and magnesium hydroxide was found to lessen relapse to 23% at one year compared to 37% on placebo. 04 This compared favourably to natural compound library cimetidine 400 mg nocte. This benefit was independent of smoking status. Figure 1 displays current treatment options for peptic ulcer disease. H2 antagonists remain the first line therapy, ranitidine being preferred in men or in those on medications metabolized by cytochrome P450 oxidase systems. In future, treatment strategies may need to be predicated on a better understanding of the role of Helicobacter pylori. This organism has excited considerable interest and probably plays an essential part in the tendency for relieved ulcers to relapse. In future, using bismuth compounds, medicines or other drugs capable of reducing this patient could become part of the strategy for treating peptic ulcers. Inflammatory bowel disease The major innovations in management of inflammatory bowel disease have been in new ways of giving the active moiety of sulphasalazine 5 amino salicyclic acid to the colon thus removing the negative effects of the sulphonamide component. Mesalazine is which can be better than sulphasalazine in maintenance treatment of colitis when assessed by sigmoidoscopic look of rectal mucosa and rectal bleeding. 05 This planning releases 5. ASA in to the colon where the pH rises above 7. 7.