“
“The “”year in review”" session is a key moment of the Osteoarthritis Research Society International (OARSI) Congress. This is a unique opportunity

for opinion leaders to summarize and comment the recent advances in one particular field of osteoarthritis research. This review is a summary of selected studies related to soluble biomarkers published between September 1st, 2010 and August 30th, 2011 and identified by a pubmed search using the terms “”biomarkers”" and “”osteoarthritis”". In addition, I have selected some works presented during the 2011 OARSI Congress. This year was dominated by the publication of a consensus paper on the qualification of osteoarthritis (OA) biomarkers by the OARSI/Food Drug Administration (FDA) Osteoarthritis Biomarkers B-Raf inhibitor drug Working Group, and of proteomes of chondrocyte vesicles, urine and serum., (C) FHPI 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.”
“BACKGROUND: This paper

assesses the functioning of the next generation of permeable pavement systems. The overall concept is to combine traditional permeable pavement systems with ground source heat pump systems. Long-term research to provide data concerning nutrient reductions and microbial activity within experimental pavement rigs is required.

RESULTS: The variability of temperature allowed for the survival of pathogenic organisms within the sub-base of permeable pavement systems. Counts of microbes and nutrient concentrations have been determined by direct observation (plate count tests) and chemical analysis, respectively. GW4869 An analysis using numerical methods indicated

99% and 95% biochemical oxygen demand and ammonia-nitrogen removal, respectively. Supplementary carbon dioxide monitoring indicated relatively high microbial activity on geotextiles and within the lower parts of the sub-base. Low oxygen concentrations were measured in the space around the geotextile, where carbon dioxide concentrations reached 2000 ppm.

CONCLUSIONS: The research enables decision-makers for the first time to assess public health risks, treatment requirements and efficiencies, and the potential for runoff recycling. The great system stability of the innovation and minor water quality data variability between individual experimental pavement systems provide good evidence for the controlled engineered application of this novel sustainable technology. (C) 2008 Society of Chemical Industry”
“Aims: Epidemiological and animal data suggest that the development of adult chronic conditions is influenced by early-life exposure-induced changes to the epigenome. This study investigates the effects of perinatal lead (Pb) exposure on DNA methylation and bodyweight in weanling mice. Materials & methods: Viable yellow agouti (A(vy)) mouse dams were exposed to 0, 2.