There are no differences in the HBeAg positive and HBeAg negative
HDV disease. Key Word(s): 1. hepatitis D; 2. hepatitis B; 3. children; 4. presentation; Presenting Author: YOGESHPURSHOTTAM HARWANI Additional Authors: PADMAVATHI CHOUDESHWARI, AJITKUMAR SHRIVASTAVA Corresponding Author: YOGESHPURSHOTTAM HARWANI Affiliations: NIMS Objective: Little is known about hepatitis B surface antigen(HBsAg) during the natural course of chronic hepatitis B infection (CHB). The aim of the study was to determine and to correlate with HBV DNA. Methods: Twenty three HBV patients were included. They were classified as immune tolerant phase(IT;n = 7). They were further classified as HBe-positive IT (n = 2)and HbeAg negetive precore mutant(PCM)IT (n = 5). Immune BAY 80-6946 clearance (IC n = 4) and low replicative phase (lr n = 12). The classification was based on ALT HBV DNA and Hbe status. Results: Median HBsAg titres were different between each phase of CHB (P < 0.05).
IT (e positive): 4.87log 10 IU/ml, IT PCM 4.17 log 10 IU/ml, IC 4.49 log 10 and lr 3.64 log 10 IU/ml in the above groups respectively. The ratio of HBsAg log 10 to HBV DNA log 10 was highest in IC 3.71 followed by lr 1.95. It was 0.67 and 0.78 in IT eAg positive and IT PCM. Conclusion: HBsAg levels were significantly different in different stages of disease. A good correlation between HBV DNA and HBsAg titres was seen in IT PCM (0.92) and moderate in IC (0.64). However, study with large sample size wll be helpful in deriving conclusions. Key Word(s): 1. HBsAg titres; 2. pre core
mutant; 3. immune toletant; Presenting Author: OUDOU NJOYA Additional Authors: CHARIFA MLN0128 mouse FOUWOU NJOYA, MARIE JOSÉ ESSI, ELIE NKWABONG, ELIE CLAUDE NDJITOYAP NDAM Corresponding Author: OUDOU NJOYA Affiliations: University Hospital Center Objective: Cameroon constitutes a high prevalence zone for viral hepatitis B (VHB). Mother-to-child transmission is considered as the main mode of transmission of hepatitis B virus (HBV) in Africa. This mode of transmission is particular in sub Saharan countries as it implies factor related to the virus, to the knowledge attitude and practices of pregnant women selleck kinase inhibitor and health personnel. The aim of this study was to identify risk factors of the mother-to-child transmission of VHB. Methods: A cross sectional study was carried out in three heath districts in the City of Yaoundé in Cameroon. We recruited all the pregnant women and heath personnel working in the obstetrics departments who accepted to participate and met the criteria of selection into the study. Pregnant women (PW) were tested freely for virus B markers, namely HBs Ag; HBe Ag; HBc anti body. Secondary, they were tested for they knowledge, attitudes and practices (KAP) vis-à-vis of VHB, excluding pregnant heath personnel (HP). Pregnant women tested positive for Hbs Ag or Hbc anti body were referred for follow up.