In this stratified analysis, no variable presented a statistically significant negative association www.selleckchem.com/products/crenolanib-cp-868596.html with mortality (Table 3).Table 3All-cause mortality risk and lipid levels in adjusted by sex, age > 75, hypertension, and diabetes (excluded body mass index <20kg/m2 and early mortality <2 years).4. DiscussionThe results indicate higher mortality among older people with lower levels of total cholesterol. Furthermore, they show no association between all-cause mortality and hypercholesterolemia, high LDL-c, low HDL-c, hypertriglyceridemia, and high non-HDL-c in this group of older adults. High levels of lipoproteins such as TC, LDL-c, and TG are widely known as risk factors for total and cardiovascular mortality in the general population .
In geriatric populations, however, this association is being studied, and conflicting results have been presented. These results depend on methodological characteristics such as age, follow-up time, and the covariables analyzed [7�C11]. Our results did not show a positive association between hyperlipidemias and all-cause mortality. In the initial analysis, even before excluding premature mortality and underweight individuals, this association was negative. Questions persist about the real role of hypercholesterolemia as a general mortality risk among older people; the association may be positive, negative, or null. The fact that other authors have not observed a positive association corroborates our results [8, 9, 11].Concerning the risk of developing cardiovascular disease, there is more evidence of the role of TC increase in the geriatric population [12, 13].
It is possible that among elderly populations, high TC levels are associated with better global health conditions. In a study carried out in Honolulu, researchers observed that high TC levels were associated with higher body mass index levels, high HDL-c, better hemoglobin levels, and greater muscular strength .Another factor that could influence analysis of lipid risk factors in older people is cardiovascular mortality before age 60 among individuals with high cholesterol.In addition to not showing a mortality increase with high liproprotein levels, data from the present study indicate that there is a higher risk in low lipoprotein levels such as TC and HDL-c. Low HDL-c levels have already been established as determinants of cardiovascular morbimortality among geriatric populations [14, 15].
In this study, we have observed that even using two different HDL-c cut-offs (<35 and 40mg/mL) , there was positive association with all-cause mortality, although not statistically significant. Batimastat This corroborates the results of other authors who have observed a similar association in samples of people aged 65 or older , 70 or older , and in the frail elderly .