The aim of the present study was therefore to determine whether the routine use of colonoscopes equipped with high-definition combined with i-Scan technology (HD+ plus i-Scan) gave a higher rate of detection of overall mucosal lesions, particularly http://www.selleckchem.com/products/BIBF1120.html of flat adenomas, than standard white-light video colonoscopes, in a consecutive series of patients undergoing screening, diagnostic or surveillance colonoscopy by different endoscopists with similar expertise, in an outpatient clinical practice setting. MATERIALS AND METHODS Data for the study were collected from the computerized database of the endoscopy unit of our tertiary referral center.

Colonoscopy records included patients�� main details and family history for colorectal cancer, indication for colonoscopy (screening, diagnostic or surveillance), type of instrument used (standard white-light or HD+ plus i-Scan), name of endoscopist, and bowel preparation, defined on the basis of a modified Ottawa scale[47]. Records for each procedure included whether the cecum was reached or not and the reason for failure (inadequate cleaning, strictures, and pain during the procedure), complications during or immediately after the procedure, and number, location and characteristics of the lesions. Polyps or protruding lesions were defined as sessile (Is) or pedunculated (Ip), and nonprotruding lesions as elevated (IIa), flat (IIb), and depressed (IIc), according to Paris classification[48]. For each lesion, histological diagnosis was recorded. Size and location of the lesions were classified as follows: 0-5 mm, 6-10 mm, 11-15 mm, 16-20 mm, 21-30 mm, > 30 mm; right and left colon.

Withdrawal time was recorded for all screening colonoscopies, being these procedures the object of other studies. Images of each lesion were stored in the database. For each patient, pO2, heart rate, and blood pressure were measured and recorded before, during and at the end of the procedure. Data collection Over a 1-year period, all consecutive screening, diagnostic and surveillance colonoscopies in outpatients done by four expert endoscopists, each of whom had done 200-400 colonoscopies/year for at least 15 years and at least Drug_discovery 50 procedures with HD+ plus i-Scan definition equipped instruments were evaluated. The four endoscopists used the two endoscopy techniques in a random fashion, depending of the availability of the instruments. Colonoscopies in subjects younger than 18 years, with genetic-associated colon cancer risk conditions, acute gastrointestinal bleeding, or inflammatory bowel disease were excluded.